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ACS Appl Mater Interfaces. 2016 May 11;8(18):11237-45. doi: 10.1021/acsami.5b12329. Epub 2016 Apr 27.

Biocompatible Hollow Polydopamine Nanoparticles Loaded Ionic Liquid Enhanced Tumor Microwave Thermal Ablation in Vivo.

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Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , No. 29 East Road Zhongguancun, Beijing 100190, P. R. China.
School of Science, Beijing Jiaotong University , No. 3 Shangyuancun Haidian District, Beijing, 100044, P. R. China.


Tumor microwave thermal therapy (MWTT) has attracted more attention because of the minimal damage to body function, convenient manipulation and low complications. Herein, a novel polydopamine (PDA) nanoparticle loading ionic liquids (ILs/PDA) as microwave susceptible agent is introduced for enhancing the selectivity and targeting of MWTT. ILs/PDA nanocomposites have an excellent microwave heating efficiency under an ultralow microwave power irradiation. Encouraging antitumor effect was observed when tumor bearing mice received ILs/PDA nanoparticles by intravenous injection and only single microwave irradiation. PDA nanoparticles with gold nanoparticles in core were constructed for tumor targeting study by ICP-MS and about 15% PDA nanoparticles were founded in tumor. Furthermore, the cytotoxicity and acute toxicity study in vivo of PDA showed the excellent biocompatibility of ILs/PDA nanocomposites. In addition, the degradation of ILs/PDA nanocomposites in simulated body fluid illustrated the low potential hazard when they entered the blood. The emergence of PDA as a novel and feasible platform for cancer thermal therapy will promote the rapid development of microwave therapy in clinics.


ionic liquids; microwave susceptible agent; microwave thermal ablation; nanoparticle; polydopamine

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