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Nat Genet. 2016 Jun;48(6):617-623. doi: 10.1038/ng.3551. Epub 2016 Apr 18.

Physical and neurobehavioral determinants of reproductive onset and success.

Author information

1
MRC Epidemiology Unit, University of Cambridge, UK.
2
deCODE genetics/Amgen, Reykjavik, Iceland.
3
School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
4
Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., East, Boston, MA 02215, USA.
5
Harvard Medical School, Boston, MA 02115, USA.
6
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
7
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
8
Department of Anthropology, University of Iceland, Reykjavik, Iceland.
9
Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
#
Contributed equally

Abstract

The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide association study of 125,667 UK Biobank participants, we identify 38 loci associated (P < 5 × 10(-8)) with age at first sexual intercourse. These findings were taken forward in 241,910 men and women from Iceland and 20,187 women from the Women's Genome Health Study. Several of the identified loci also exhibit associations (P < 5 × 10(-8)) with other reproductive and behavioral traits, including age at first birth (variants in or near ESR1 and RBM6-SEMA3F), number of children (CADM2 and ESR1), irritable temperament (MSRA) and risk-taking propensity (CADM2). Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and lower educational attainment. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes.

PMID:
27089180
PMCID:
PMC5238953
DOI:
10.1038/ng.3551
[Indexed for MEDLINE]
Free PMC Article

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