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Environ Toxicol Pharmacol. 2016 Jun;44:25-9. doi: 10.1016/j.etap.2016.04.004. Epub 2016 Apr 9.

Recent advances (2010-2015) in studies of cerium oxide nanoparticles' health effects.

Author information

1
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira Taipa, Macau 999078, China; Shanghai Institute of Occupational Safety and Health (SIOSH), 369 North Chengdu Road, Shanghai 200041, China. Electronic address: jian_2001@sina.com.
2
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira Taipa, Macau 999078, China.
3
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira Taipa, Macau 999078, China. Electronic address: bian_ying_um@sina.com.

Abstract

Cerium oxide nanoparticles, widespread applied in our life, have attracted much concern for their human health effects. However, most of the works addressing cerium oxide nanoparticles toxicity have only used in vitro models or in vivo intratracheal instillation methods. The toxicity studies have varied results and not all are conclusive. The information about risk assessments derived from epidemiology studies is severely lacking. The knowledge of occupational safety and health (OSH) for exposed workers is very little. Thus this review focuses on recent advances in studies of toxicokinetics, antioxidant activity and toxicity. Additionally, aim to extend previous health effects assessments of cerium oxide nanoparticles, we summarize the epidemiology studies of engineered cerium oxide nanoparticles used as automotive diesel fuel additive, aerosol particulate matter in air pollution, other industrial ultrafine and nanoparticles (e.g., fumes particles generated in welding and flame cutting processes).

KEYWORDS:

Antioxidant activity; Cerium oxide nanoparticles; Epidemiology studies; Health effects; Toxicity

PMID:
27088851
DOI:
10.1016/j.etap.2016.04.004
[Indexed for MEDLINE]

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