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Pharm Pat Anal. 2016 May;5(3):169-81. doi: 10.4155/ppa-2016-0003. Epub 2016 Apr 18.

Mangiferin: a promising anticancer bioactive.

Author information

1
University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, 160 014, India.
2
UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles & Nanocomposites (Biomedical Sciences), Panjab University, Chandigarh, 160 014, India.
3
School of Pharmacy & Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, UK.

Abstract

Of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, in other words, oxidative stress. Mangiferin, a therapeutically active C-glucosylated xanthone, is extracted from pulp, peel, seed, bark and leaf of Mangifera indica. These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps in stalling the progression of carcinogenesis. The current review article emphasizes an updated account on the patents published on the chemopreventive action of mangiferin, apoptosis induction made on various cancer cells, along with proposed antioxidative activities and patent mapping of other important therapeutic properties. Considering it as promising polyphenol, this paper would also summarize the diverse molecular targets of mangiferin.

KEYWORDS:

anti-inflammatory; antioxidants; apoptosis; bioactive; chemoprotective; homomangiferin; isomangiferin; multiple molecular targets

PMID:
27088726
DOI:
10.4155/ppa-2016-0003
[Indexed for MEDLINE]

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