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Nat Mater. 2016 Jul;15(7):782-791. doi: 10.1038/nmat4624. Epub 2016 Apr 18.

Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex.

Yu KJ#1,2, Kuzum D#3,4,5, Hwang SW6, Kim BH2,7, Juul H8, Kim NH2,7, Won SM1,2, Chiang K9, Trumpis M9, Richardson AG4,10, Cheng H11, Fang H2,7, Thomson M3,4,12, Bink H3,4, Talos D8, Seo KJ2,7, Lee HN2,13, Kang SK2,7, Kim JH2,7, Lee JY2,13, Huang Y14, Jensen FE4,8, Dichter MA4,8, Lucas TH4,10, Viventi J9, Litt B3,4,8, Rogers JA1,2,7.

Author information

1
Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
2
Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
3
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
4
Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
5
Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, CA 92093.
6
KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 136-701, Republic of Korea.
7
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
8
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
9
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
10
Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
11
Department of Engineering Science and Mechanics, Penn State University, University Park, PA 16802, USA.
12
Department of Chemical and Biomolecular Engineering University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
13
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana- Champaign, Urbana, IL 61801, USA.
14
Department of Mechanical Engineering and Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
#
Contributed equally

Abstract

Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.

PMID:
27088236
PMCID:
PMC4919903
DOI:
10.1038/nmat4624
[Indexed for MEDLINE]
Free PMC Article

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