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Aliment Pharmacol Ther. 2016 Jun;43(11):1178-85. doi: 10.1111/apt.13619. Epub 2016 Apr 18.

Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia.

Author information

1
Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
2
Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
3
Department of Gastroenterology, Bernhoven Hospital, Uden, The Netherlands.
4
Department of Gastroenterology, Canisius-Wilhelmina-Hospital, Nijmegen, The Netherlands.

Abstract

BACKGROUND:

Proton pump inhibitors (PPI) are among the most widely prescribed drugs to treat gastric acid-related disorders. PPI-induced hypomagnesaemia, a defect in intestinal absorption of Mg(2+) , can be a severe side effect of chronic PPI use.

AIM:

To restore serum Mg(2+) concentrations in PPI-induced hypomagnesaemia patients by dietary supplementation with inulin fibres.

METHODS:

Eleven patients with PPI-induced hypomagnesaemia and 10 controls were treated with inulin (20 g/day). Each trial consisted of two cycles of 14-day inulin treatment followed by a washout period of 14 days. Patients continued to use their PPI. Serum Mg(2+) levels served as the primary endpoint.

RESULTS:

Inulin significantly enhanced serum Mg(2+) levels from 0.60 to 0.68 mmol/L in PPI-induced hypomagnesaemia patients, and from 0.84 to 0.93 mmol/L in controls. As a consequence 24 h urinary Mg(2+) excretion was significantly increased in patients with PPI-induced hypomagnesaemia (0.3-2.2 mmol/day). Symptoms related to hypomagnesaemia, including muscle cramps and paraesthesia, were reduced during intervention with inulin.

CONCLUSION:

Inulin increases serum Mg(2+) concentrations under PPI maintenance in patients with PPI-induced hypomagnesaemia.

PMID:
27086738
DOI:
10.1111/apt.13619
[Indexed for MEDLINE]
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