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Curr Opin Cell Biol. 2016 Oct;42:29-37. doi: 10.1016/j.ceb.2016.04.001. Epub 2016 Apr 14.

Wound repair: a showcase for cell plasticity and migration.

Author information

1
King's College London - Centre for Molecular and Cellular Biology of Inflammation, London SE1 1UL, UK. Electronic address: Tanya.shaw@kcl.ac.uk.
2
Schools of Biochemistry and Physiology & Pharmacology, University of Bristol, Bristol BS8 1TD, UK; School of Medicine, Cardiff University, Cardiff CF14 4XN, UK; Lee Kong Chiang School of Medicine, Nanyang Technologicial University, Singapore. Electronic address: Paul.martin@bristol.ac.uk.

Abstract

A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connective tissue, the immune cells that counter infections, and endothelial cells that re-establish blood supply and facilitate the immune response - all of these cells are 'dynamic' in that they are activated by immediate wound cues, they reprogram to adopt cell behaviours essential for repair including migration, and finally they must resolve. In adult tissues, repair is unique in its requirement for dramatic cell changes and movements otherwise associated only with development and disease.

PMID:
27085790
DOI:
10.1016/j.ceb.2016.04.001
[Indexed for MEDLINE]

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