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J Comput Neurosci. 2016 Jun;40(3):347-62. doi: 10.1007/s10827-016-0601-0. Epub 2016 Apr 16.

Impact of slow K(+) currents on spike generation can be described by an adaptive threshold model.

Author information

1
Principles of Informatics Research Division, National Institute of Informatics, 2-1-2 Hitotsubashi, Chiyoda-ku, Tokyo, Japan. r-koba@nii.ac.jp.
2
Department of Informatics, SOKENDAI (The Graduate University for Advanced Studies), 2-1-2 Hitotsubashi, Chiyoda-ku, Tokyo, Japan. r-koba@nii.ac.jp.
3
Department of Human and Computer Intelligence, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan.

Abstract

A neuron that is stimulated by rectangular current injections initially responds with a high firing rate, followed by a decrease in the firing rate. This phenomenon is called spike-frequency adaptation and is usually mediated by slow K(+) currents, such as the M-type K(+) current (I M ) or the Ca(2+)-activated K(+) current (I AHP ). It is not clear how the detailed biophysical mechanisms regulate spike generation in a cortical neuron. In this study, we investigated the impact of slow K(+) currents on spike generation mechanism by reducing a detailed conductance-based neuron model. We showed that the detailed model can be reduced to a multi-timescale adaptive threshold model, and derived the formulae that describe the relationship between slow K(+) current parameters and reduced model parameters. Our analysis of the reduced model suggests that slow K(+) currents have a differential effect on the noise tolerance in neural coding.

KEYWORDS:

Conductance-based models; Integrate-and-fire models; Model reduction; Slow K+ currents; Spike generation mechanism

PMID:
27085337
PMCID:
PMC4860204
DOI:
10.1007/s10827-016-0601-0
[Indexed for MEDLINE]
Free PMC Article

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