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World J Urol. 2016 Dec;34(12):1611-1619. Epub 2016 Apr 15.

Use of androgen deprivation therapy as salvage treatment after primary therapy for clinically localized prostate cancer.

Author information

1
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3300 Whitehaven Street, NW, Suite 4100, Washington, DC, 20007, USA. zf54@georgetown.edu.
2
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3300 Whitehaven Street, NW, Suite 4100, Washington, DC, 20007, USA.
3
Kaiser Permanente Southern California, Pasadena, CA, USA.
4
Boston University School of Public Health, Boston, MA, USA.
5
Kaiser Permanente Northern California, Oakland, CA, USA.
6
Henry Ford Hospital, Detroit, MI, USA.
7
Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
8
Massachusetts General Hospital, Boston, MA, USA.

Abstract

PURPOSE:

The optimal use of androgen deprivation therapy as salvage treatment (sADT) for men after initial prostatectomy or radiotherapy for clinically localized prostate cancer is undefined. We describe patterns of sADT use and investigate clinical and sociodemographic characteristics of insured men who received sADT versus surveillance in managed care settings.

METHODS:

Using comprehensive electronic health records and cancer registry data from three integrated health plans, we identified all men with newly diagnosed clinically localized prostate cancer between 1995 and 2009 who received either prostatectomy (n = 16,445) or radiotherapy (n = 19,531) as their primary therapy. We defined sADT based on the timing of ADT following primary therapy and stage of cancer. We fit Cox proportional hazard models to identify sociodemographic characteristics and clinical factors associated with sADT.

RESULTS:

With a median follow-up of 6 years (range 2-15 years), 13 % of men who underwent primary prostatectomy or radiotherapy received sADT. After adjusting for selected covariates, sADT was more likely to be used in men who were older (e.g., HR 1.70, 95 % CI 1.48-1.96 or HR 1.33, 95 % CI 1.17-1.52 for age 70+ relative to age 35-59 for primary prostatectomy or radiotherapy, respectively), were African-American, had a short PSA doubling time, had a higher pre-treatment risk of progression, had more comorbidities, and received adjuvant ADT for initial disease.

CONCLUSIONS:

In men with localized prostate cancer in community practice initially treated with prostatectomy or radiotherapy, sADT after primary treatment was more frequent for men at greater risk of death from prostate cancer, consistent with practice guidelines.

KEYWORDS:

Androgen deprivation therapy; Localized prostate cancer; Salvage treatment

PMID:
27084777
PMCID:
PMC5065786
DOI:
10.1007/s00345-016-1823-5
[Indexed for MEDLINE]
Free PMC Article

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