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Adv Ther. 2016 Apr;33(4):553-79. doi: 10.1007/s12325-016-0311-z. Epub 2016 Mar 19.

Cervical Lymph Node Metastasis in Adenoid Cystic Carcinoma of the Larynx: A Collective International Review.

Author information

1
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
2
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
3
University of Udine School of Medicine, Udine, Italy.
4
Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
5
Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
6
Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, Spain.
7
Fundación de Investigación e Innovación Biosanitaria del Principado de Asturias, Oviedo, Spain.
8
Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ, USA.
9
Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
10
Department of Pathology, Allegiance Health, Jackson, MI, USA.
11
Southern California Permanente Medical Group, Woodland Hills, CA, USA.
12
Department of Pathology, Beth Israel Medical Center, New York, NY, USA.
13
Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
14
Department of Head and Neck Surgery, Head and Neck Oncology Program, St Luc University Hospital and King Albert II Cancer Institute, Brussels, Belgium.
15
Department of Otolaryngology-Head and Neck Surgery, Nottingham University Hospitals, Queens Medical Centre Campus, Nottingham, UK.
16
European Salivary Gland Society, Geneva, Switzerland.
17
University Pathologists, Providence, RI, USA.
18
University Pathologists, Fall River, MA, USA.
19
Departments of Surgery and Otolaryngology - Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
20
Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
21
Oral and Maxillofacial Pathology, School of Dentistry, University of Liverpool and Cellular Pathology, Liverpool Clinical Laboratories, Liverpool, UK.
22
Otorhinolaryngology-Head and Neck Surgery and Department of Oncology, Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
23
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
24
Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic.
25
Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal.
26
Department of Otolaryngology-Head and Neck Surgery, Philipp University, Marburg, Germany.
27
Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
28
Division of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA.
29
Department of Surgery, Banner MD Anderson Cancer Center, Gilbert, AZ, USA.
30
Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
31
Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
32
Department of Radiation Oncology, University of Florida, Gainesville, FL, USA.
33
Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
34
Coordinator of the International Head and Neck Scientific Group, Padua, Italy. a.ferlito@uniud.it.

Abstract

Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the larynx is uncommon, it is difficult to standardize a treatment protocol. One of the controversial points is the decision whether or not to perform an elective neck dissection on these patients. Because there is contradictory information about this issue, we have critically reviewed the literature from 1912 to 2015 on all reported cases of AdCC of the larynx in order to clarify this issue. During the most recent period of our review (1991-2015) with a more exact diagnosis of the tumor histology, 142 cases were observed of AdCC of the larynx, of which 91 patients had data pertaining to lymph node status. Eleven of the 91 patients (12.1%) had nodal metastasis and, based on this low proportion of patients, routine elective neck dissection is therefore not recommended.

KEYWORDS:

Adenoid cystic carcinoma; Clinical protocols; Elective neck dissection; Larynx; Lymph node metastasis; Neck; Oncology; Treatment

PMID:
27084720
PMCID:
PMC4846710
DOI:
10.1007/s12325-016-0311-z
[Indexed for MEDLINE]
Free PMC Article

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