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Int J Hematol. 2016 May;103(5):487-97. doi: 10.1007/s12185-016-1984-4. Epub 2016 Mar 23.

Cell cycle regulation of hematopoietic stem or progenitor cells.

Hao S1, Chen C1, Cheng T2,3,4.

Author information

1
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China.
2
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China. chengtao@ihcams.ac.cn.
3
Department of Stem Cell and Regenerative Medicine, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China. chengtao@ihcams.ac.cn.
4
Collaborative Innovation Center for Cancer Medicine, Tianjin, 300020, China. chengtao@ihcams.ac.cn.

Abstract

The highly regulated process of blood production is achieved through the hierarchical organization of hematopoietic stem cell (HSC) subsets and their progenies, which differ in self-renewal and differentiation potential. Genetic studies in mice have demonstrated that cell cycle is tightly controlled by the complex interplay between extrinsic cues and intrinsic regulatory pathways involved in HSC self-renewal and differentiation. Deregulation of these cellular programs may transform HSCs or hematopoietic progenitor cells (HPCs) into disease-initiating stem cells, and can result in hematopoietic malignancies such as leukemia. While previous studies have shown roles for some cell cycle regulators and related signaling pathways in HSCs and HPCs, a more complete picture regarding the molecular mechanisms underlying cell cycle regulation in HSCs or HPCs is lacking. Based on accumulated studies in this field, the present review introduces the basic components of the cell cycle machinery and discusses their major cellular networks that regulate the dormancy and cell cycle progression of HSCs. Knowledge on this topic would help researchers and clinicians to better understand the pathogenesis of relevant blood disorders and to develop new strategies for therapeutic manipulation of HSCs.

KEYWORDS:

Cell cycle; Hematopoiesis; Hematopoietic stem cells; Quiescence; Self-renewal

PMID:
27084253
DOI:
10.1007/s12185-016-1984-4
[Indexed for MEDLINE]

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