Format

Send to

Choose Destination
J Hepatol. 2016 Apr;64(1 Suppl):S71-S83. doi: 10.1016/j.jhep.2016.01.026.

Adaptive immunity in HBV infection.

Author information

1
Emerging Infectious Diseases (EID) Program, Duke-NUS Medical School, Singapore; Viral Hepatitis Laboratory, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*STAR), Singapore. Electronic address: antonio@duke-nus.edu.sg.
2
Divisione Malattie Infettive, Ospdale Maggiore Parma, Parma, Italy.

Abstract

During hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately determines HBV infection outcome. In this review, in addition to summarizing the present state of knowledge of HBV-adaptive immunity, we will highlight controversies and uncertainties concerning the HBV-specific B and T lymphocyte response, and propose future directions for research aimed at the generation of more efficient immunotherapeutic strategies.

KEYWORDS:

Antiviral immunity; B lymphocytes; Immunodominance; T cell exhaustion; T lymphocytes

PMID:
27084039
DOI:
10.1016/j.jhep.2016.01.026
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center