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Genes Dev. 2016 Apr 15;30(8):878-80. doi: 10.1101/gad.281519.116.

MOMP in the absence of BH3-only proteins.

Author information

1
Interfaculty Institute of Biochemistry (IFIB), University of Tübingen 72076, Tübingen, Germany;
2
Division of Developmental Immunology, Biocenter, Medical University Innsbruck, A-6020 Innsbruck, Austria; Tyrolean Cancer Research Institute, A-6020 Innsbruck, Austria.

Abstract

The minimum requirement for mitochondrial apoptosis has been controversial ever since the discovery of BCL-2 as a cell death regulator. In this issue ofGenes&Development, O'Neill and colleagues (pp. 973-988) end a long-standing debate by creating a cellular system free of BCL-2 family proteins, thereby identifying the outer mitochondrial membrane rather than BH3-only proteins as the only requirement for BAX/BAK activation and mitochondrial outer membrane permeabilization (MOMP).

KEYWORDS:

BH3-only; Bax/Bak activation; anti-apoptotic Bcl-2 proteins; outer mitochondrial membrane

PMID:
27083995
PMCID:
PMC4840294
DOI:
10.1101/gad.281519.116
[Indexed for MEDLINE]
Free PMC Article

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