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Pediatr Surg Int. 2016 Jun;32(6):565-9. doi: 10.1007/s00383-016-3894-1. Epub 2016 Apr 15.

Patients exposed to diagnostic head and neck radiation for the management of shunted hydrocephalus have a significant risk of developing thyroid nodules.

Author information

1
Division of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, 700 Children's Drive, ED320, Columbus, OH, 43205, USA. Jennifer.aldrink@nationwidechildrens.org.
2
Department of Radiology, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
3
The Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
4
Division of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, 700 Children's Drive, ED320, Columbus, OH, 43205, USA.
5
Department of Biostatistics, Nationwide Children's Hospital, Columbus, OH, USA.

Abstract

PURPOSE:

External radiation to the head and neck can lead to an increased incidence of thyroid nodules. We investigated whether patients requiring repeated head and neck imaging for the management of shunted hydrocephalus had a higher incidence of ultrasound-detected thyroid nodules compared to reports of comparable age.

METHODS:

Patients treated at our institution for shunted hydrocephalus from 1990 to 2003 were contacted. Enroled patients underwent a thyroid ultrasound. Demographic data and radiation exposure history were obtained retrospectively.

RESULTS:

Thyroid nodules were identified sonographically in 15/112 patients (13.6 %). Patients with thyroid nodules were older (mean 24.3 ± 7.6 years) than those without (mean 18.4 ± 8.0 years) (p = 0.005). Those with a detectable thyroid nodule had a longer follow up time compared to those who did not (mean 21.9 ± 5.5 vs. 15.1 ± 7 years, respectively) (p = 0.018).

CONCLUSION:

Patients with shunted hydrocephalus are exposed to substantial head and neck radiation from diagnostic imaging and have a higher incidence of thyroid nodules detected by ultrasonography. These patients should be provided ongoing surveillance for detection of thyroid nodules and the possibility of malignancy.

KEYWORDS:

Hydrocephalus; Radiation; Thyroid malignancy; Thyroid nodule

PMID:
27083898
DOI:
10.1007/s00383-016-3894-1
[Indexed for MEDLINE]

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