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Carbohydr Polym. 2016 Jun 25;144:68-75. doi: 10.1016/j.carbpol.2016.02.027. Epub 2016 Feb 10.

Water-insoluble thin films from palmitoyl hyaluronan with tunable properties.

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Contipro Biotech s.r.o., Dolní Dobrouč 401, Dolní Dobrouč 561 02, Czech Republic. Electronic address:
Contipro Biotech s.r.o., Dolní Dobrouč 401, Dolní Dobrouč 561 02, Czech Republic.
Contipro Pharma a.s., Dolní Dobrouč 401, Dolní Dobrouč 561 02, Czech Republic.
Department of Medical Biophysics, Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University, Hnĕvotínská 3, Olomouc 775 15, Czech Republic.
Centre of Polymer Systems, Tomas Bata University in Zlín, Třída Tomáše Bati 5678, Zlín 760 01, Czech Republic.


Hyaluronan (HA) films exhibit properties suitable for various biomedical applications, but the solubility of HA limits their use in aqueous environments. Therefore, we developed water insoluble films based on palmitoyl esters of HA (pHA). Films were prepared from pHA samples with various degrees of substitution (DS) and molecular weights and their mechanical properties and swelling were characterized. Additionally, scanning electron microscopy and atomic force microscopy were used for visualization. Despite being prepared by solution casting, the films had a very smooth surface and were homogeneous in thickness. The film properties were in accordance with the polymer DS and molecular weight, enabling to tailor them for future applications by choosing a suitable pHA material. The behavior of the films toward cells was assessed in vitro. All films were non-cytotoxic and showed no adhesion of cells. These results show that the developed films are suitable candidates for various biomedical applications such as tissue engineering or wound healing.


Palmitoyl hyaluronan; Solution casting; Swelling; Tensile properties; Thin film

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