Format

Send to

Choose Destination
Cell Signal. 2016 Aug;28(8):917-23. doi: 10.1016/j.cellsig.2016.04.005. Epub 2016 Apr 13.

β-Hydroxybutyrate: A signaling metabolite in starvation response?

Author information

1
Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico.
2
Laboratorio de Fisiopatología Renal, Departamento de Nefrología, Instituto Nacional de Cardiología - Ignacio Chávez, Mexico City, Mexico.
3
Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico. Electronic address: pedraza@unam.mx.

Abstract

Ketone bodies β-hydroxybutyrate (BHB) and acetoacetate are important metabolic substrates for energy production during prolonged fasting. However, BHB also has signaling functions. Through several metabolic pathways or processes, BHB modulates nutrient utilization and energy expenditure. These findings suggest that BHB is not solely a metabolic intermediate, but also acts as a signal to regulate metabolism and maintain energy homeostasis during nutrient deprivation. We briefly summarize the metabolism and emerging physiological functions of ketone bodies and highlight the potential role for BHB as a signaling molecule in starvation response.

KEYWORDS:

Autophagy; Energy expenditure; Signaling; Starvation; β-Hydroxybutyrate

PMID:
27083590
DOI:
10.1016/j.cellsig.2016.04.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center