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Mol Ther. 2016 Apr;24(4):660-1. doi: 10.1038/mt.2016.47.

Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV.

Nault JC1,2,3,4,5, Mami I1,2,3,4, La Bella T1,2,3,4, Datta S1,2,3,4, Imbeaud S1,2,3,4, Franconi A1,2,3,4, Mallet M1,2,3,4, Couchy G1,2,3,4, Letouzé E1,2,3,4, Pilati C1,2,3,4, Verret B1,4, Blanc JF6,7, Balabaud C7, Calderaro J1,2,3,4,8, Laurent A9,10, Letexier M11, Bioulac-Sage P7,12, Calvo F1,2,3,4,13, Zucman-Rossi J1,2,3,4,14.

Author information

1
INSERM, UMR 1162, Génomique Fonctionnelle des Tumeurs Solides, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
2
Université Paris Descartes, Labex Immuno-Oncology, Sorbonne Paris Cité, Paris, France.
3
Université Paris 13, Sorbonne Paris Cité, UFR SMBH, Bobigny, France.
4
Université Paris Diderot, IUH, Paris, France.
5
APHP, Hôpitaux Universitaires Paris-Seine Saint-Denis, Site Jean Verdier, Pôle d'Activité Cancérologique Spécialisée, Service d'Hépatologie, Bondy, France.
6
CHU de Bordeaux, Department of Hepatology, Hôpital Saint-André, Bordeaux, France.
7
INSERM, UMR 1053; Université de Bordeaux, Bordeaux, France.
8
Assistance Publique-Hôpitaux de Paris, Department of Pathology, CHU Henri Mondor, Créteil, France.
9
Assistance Publique-Hôpitaux de Paris, Department of Digestive and Hepatobiliary Surgery, CHU Henri Mondor, Créteil, France.
10
INSERM, U955, Créteil, France.
11
IntegraGen, Evry, France.
12
CHU de Bordeaux, Pellegrin Hospital, Department of Pathology, Bordeaux, France.
13
Institut Gustave Roussy, Core Europe, Villejuif, France.
14
Assistance Publique-Hôpitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France.
PMID:
27081717
PMCID:
PMC4886947
DOI:
10.1038/mt.2016.47
[Indexed for MEDLINE]
Free PMC Article

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