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Childs Nerv Syst. 2016 Jun;32(6):1057-60. doi: 10.1007/s00381-016-3074-6. Epub 2016 Apr 14.

Microcephaly and Zika virus: neonatal neuroradiological aspects.

Author information

1
Department of Neurosurgery, Federal University of Sao Paulo, Rua Botucatu, 591, conj 41, Sao Paulo, SP, 04023-062, Brazil. sergiocavalheironeuro@gmail.com.
2
Neurosurgery Service of Hospital da Restauração, Recife, Pernambuco, Brazil.
3
Department of Neurosurgery, Federal University of Sao Paulo, Rua Botucatu, 591, conj 41, Sao Paulo, SP, 04023-062, Brazil.
4
Department of Obstetrics, Federal University of Sao Paulo, Sao Paulo, SP, Brazil.
5
Department of Diagnostic Imaging, Federal University of Sao Paulo, Sao Paulo, SP, Brazil.

Abstract

PURPOSE:

The aim of this study is to describe some radiological features in the newborns with microcephaly caused by Zika virus infection during pregnancy.

METHODS:

We radiologically analyzed 13 cases of newborns with microcephaly born to mothers who were infected by the Zika virus in the early stage of pregnancy.

RESULTS:

The most frequently observed radiological findings were microcephaly and decreased brain parenchymal volume associated with lissencephaly, ventriculomegaly secondary to the lack of brain tissue (not hypertensive), and coarse and anarchic calcifications mainly involving the subcortical cortical transition, and the basal ganglia.

CONCLUSIONS:

Although it cannot be concluded that there is a definitive pathognomonic radiographic pattern of microcephaly caused by Zika virus, gross calcifications and anarchic distribution involving the subcortical cortical transition and the basal ganglia, in association with lissencephaly and in the absence of hypertensive ventriculomegaly, are characteristic of this type of infection.

KEYWORDS:

Aedes aegypti; Intracranial calcifications; Lissencephaly; Microcephaly; Ventriculomegaly; Zika virus

PMID:
27080092
PMCID:
PMC4882355
DOI:
10.1007/s00381-016-3074-6
[Indexed for MEDLINE]
Free PMC Article

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