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Trends Cardiovasc Med. 2016 Aug;26(6):515-23. doi: 10.1016/j.tcm.2016.03.001. Epub 2016 Mar 10.

Cardiovascular toxicity of nicotine: Implications for electronic cigarette use.

Author information

1
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, Department of Medicine, University of California, San Francisco, San Francisco, CA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA; Center for Tobacco Control Research and Education, University of California, San Francisco, CA. Electronic address: Neal.Benowitz@ucsf.edu.
2
Center for Tobacco Control Research and Education, University of California, San Francisco, CA.

Abstract

The cardiovascular safety of nicotine is an important question in the current debate on the benefits vs. risks of electronic cigarettes and related public health policy. Nicotine exerts pharmacologic effects that could contribute to acute cardiovascular events and accelerated atherogenesis experienced by cigarette smokers. Studies of nicotine medications and smokeless tobacco indicate that the risks of nicotine without tobacco combustion products (cigarette smoke) are low compared to cigarette smoking, but are still of concern in people with cardiovascular disease. Electronic cigarettes deliver nicotine without combustion of tobacco and appear to pose low-cardiovascular risk, at least with short-term use, in healthy users.

KEYWORDS:

Cardiovascular disease; Cigarette smoking; Electronic cigarettes; Nicotine

PMID:
27079891
PMCID:
PMC4958544
DOI:
10.1016/j.tcm.2016.03.001
[Indexed for MEDLINE]
Free PMC Article

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