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Cytokine Growth Factor Rev. 2016 Oct;31:37-48. doi: 10.1016/j.cytogfr.2016.03.014. Epub 2016 Apr 6.

The role of adiponectin in obesity-associated female-specific carcinogenesis.

Author information

1
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States; Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, Odisha 760 007, India. Electronic address: pganji@emory.edu.
2
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States; Department of Microbiology, Banasthali University, Banasthali, Rajasthan 304022, India. Electronic address: rajitha.balney@wellstar.org.
3
Department of Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh 500085, India. Electronic address: biotechaliya@gmail.com.
4
Department of Radiation Oncology, Cancer Biology Division, School of Medicine, Washington University in Saint Louis, St. Louis, MO 63110, United States. Electronic address: rkotipatruni@uchicago.edu.
5
Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom. Electronic address: madanraj.appiah@gmail.com.
6
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States. Electronic address: alhammo@emory.edu.
7
Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States. Electronic address: dpark33@emory.edu.
8
Office of Regulatory Science, Food and Drug Administration, Rockville, MD 20857, United States. Electronic address: srinivasulu.chigurupati@fda.hhs.gov.
9
Department of Microbiology, Banasthali University, Banasthali, Rajasthan 304022, India. Electronic address: aafroj@banasthali.in.
10
Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, Odisha 760 007, India. Electronic address: sp.zool@buodisha.edu.in.

Abstract

Adipose tissue is a highly vascularized endocrine organ, and its secretion profiles may vary with obesity. Adiponectin is secreted by adipocytes that make up adipose tissue. Worldwide, obesity has been designated a serious health problem among women and is associated with a variety of metabolic disorders and an increased risk of developing cancer of the cervix, ovaries, uterus (uterine/endometrial), and breast. In this review, the potential link between obesity and female-specific malignancies is comprehensively presented by discussing significant features of the intriguing and complex molecule, adiponectin, with a focus on recent findings highlighting its molecular mechanism of action in female-specific carcinogenesis.

KEYWORDS:

Adiponectin; Breast cancer; Cervical cancer; Endometrial cancer; Obesity; Ovarian cancer

PMID:
27079372
DOI:
10.1016/j.cytogfr.2016.03.014
[Indexed for MEDLINE]

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