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Oncotarget. 2017 Mar 21;8(12):18699-18711. doi: 10.18632/oncotarget.8627.

Association of coffee consumption with risk of colorectal cancer: a meta-analysis of prospective cohort studies.

Author information

1
Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
2
Bao'an Central Hospital of Shenzhen, Shenzhen, Guangdong, China.
3
Department of Management, School of Economics and Management, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, China.
4
Department of Pathophysiology, Shenyang Medical College, Shenyang, Liaoning, China.
5
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, Changping, China.
6
Division of Health System, Policy and Management, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China.

Abstract

A meta-analysis was performed to assess the association of coffee consumption with colorectal cancer and to investigate the shape of the association. Relevant prospective cohort studies were identified by a comprehensive search of the PubMed, Embase and Web of Science databases from their inception through August 2015. Either a random-effects model or fixed-effects model was used to compute the pooled risk estimates when appropriate. Linear and nonlinear dose-response meta-analyses were also performed. Nineteen prospective cohort studies involving 2,046,575 participants and 22,629 patients with colorectal cancer were included. The risk of colon cancer was decreased by 7% for every 4 cups per day of coffee (RR=0.93, 95%CI, 0.88-0.99; P=0.199). There was a threshold approximately five cups of coffee per day, and the inverse association for colorectal cancer appeared to be stronger at a higher range of intake. However, a nonlinear association of rectal cancer with coffee consumption was not observed (P for nonlinearity = 0.214). In conclusion, coffee consumption is significantly associated with a decreased risk of colorectal cancer at ≥ 5 cups per day of coffee consumption. The findings support the recommendations of including coffee as a healthy beverage for the prevention of colorectal cancer.

KEYWORDS:

coffee; colorectal cancer; epidemiology; meta-analysis; prospective cohort

PMID:
27078843
PMCID:
PMC5386640
DOI:
10.18632/oncotarget.8627
[Indexed for MEDLINE]
Free PMC Article

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