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Elife. 2016 Apr 14;5. pii: e13141. doi: 10.7554/eLife.13141.

Distributed task-specific processing of somatosensory feedback for voluntary motor control.

Author information

1
Centre for Neuroscience Studies, Queen's Univertsity, Kingston, Canada.
2
Brain Health Institute, Rutgers Biomedical and Health Sciences, New Jersey, United States.
3
Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Robarts Research Institute, University of Western Ontario, Ontario, Canada.
4
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.
5
Department of Medicine, Queen's University, Kingston, Canada.

Abstract

Corrective responses to limb disturbances are surprisingly complex, but the neural basis of these goal-directed responses is poorly understood. Here we show that somatosensory feedback is transmitted to many sensory and motor cortical regions within 25 ms of a mechanical disturbance applied to the monkey's arm. When limb feedback was salient to an ongoing motor action (task engagement), neurons in parietal area 5 immediately (~25 ms) increased their response to limb disturbances, whereas neurons in other regions did not alter their response until 15 to 40 ms later. In contrast, initiation of a motor action elicited by a limb disturbance (target selection) altered neural responses in primary motor cortex ~65 ms after the limb disturbance, and then in dorsal premotor cortex, with no effect in parietal regions until 150 ms post-perturbation. Our findings highlight broad parietofrontal circuits that provide the neural substrate for goal-directed corrections, an essential aspect of highly skilled motor behaviors.

KEYWORDS:

computational biology; cortical response; mechanical perturbation; motor control; non-human primates; rhesus macaque; sensory feedback; systems biology; task dependency

PMID:
27077949
PMCID:
PMC4876645
DOI:
10.7554/eLife.13141
[Indexed for MEDLINE]
Free PMC Article

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