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Eur Respir J. 2016 Jul;48(1):82-91. doi: 10.1183/13993003.00975-2015. Epub 2016 Apr 13.

Oxygen desaturation in 6-min walk test is a risk factor for adverse outcomes in COPD.

Author information

1
Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway marie.waatevik@helse-bergen.no.
2
Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway.
3
Dept of Clinical Science, University of Bergen, Bergen, Norway Dept of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
4
Dept of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.
5
Dept of Clinical Science, University of Bergen, Bergen, Norway.
6
Dept of Clinical Science, University of Bergen, Bergen, Norway Dept of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.

Abstract

The 6-min walk test (6MWT) is an exercise test that measures functional status in chronic obstructive pulmonary disease (COPD) patients and provides information on oxygen desaturation. We investigated oxygen desaturation during 6MWT as a risk factor for important COPD outcomes: mortality, frequency of exacerbations, decline in lung function and decline in lean body mass.433 COPD patients were included in the Bergen COPD Cohort Study 2006-2009, and followed-up for 3 years. Patients were characterised using spirometry, bioelectrical impedance measurements, Charlson comorbidity score, exacerbation history, smoking and arterial blood gases. 370 patients completed the 6MWT at the baseline of the study. Information on all-cause mortality was collected in 2011.Patients who experienced oxygen desaturation during the 6MWT had an approximately twofold increased risk of death (hazard ratio 2.4, 95% CI 1.2-5.1), a 50% increased risk for experiencing later COPD exacerbations (incidence rate ratio 1.6, 95% CI 1.1-2.2), double the yearly rate of decline in both forced vital capacity and forced expiratory volume in 1 s (3.2% and 1.7% versus 1.7% and 0.9%, respectively) and manifold increased yearly rate of loss of lean body mass (0.18 kg·m(-2) versus 0.03 kg·m(-2) among those who did not desaturate).Desaturating COPD patients had a significantly worse prognosis than non-desaturating COPD patients, for multiple important disease outcomes.

PMID:
27076586
DOI:
10.1183/13993003.00975-2015
[Indexed for MEDLINE]
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