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HLA. 2016 May;87(5):375-80. doi: 10.1111/tan.12795. Epub 2016 Apr 13.

KIR genotypic diversity in Portuguese and analysis of KIR gene allocation after allogeneic hematopoietic stem cell transplantation.

Author information

1
Lisbon Center for Blood and Transplantation, Instituto Português de Sangue e Transplantação, Lisbon, Portugal.
2
Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics and Evolution-Anthropology Unit, University of Geneva, Geneva, Switzerland.
3
Transplantation Immunology Unit & National Reference Laboratory for Histocompatibility, Department of Genetic and Laboratory Medicine, Geneva University Hospital, Geneva, Switzerland.
4
Hematology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, EPE, Lisbon, Portugal.
5
Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.
6
CEDOC, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal.

Abstract

The diversity of killer-cell immunoglobulin-like receptors (KIR) genes was evaluated in Portuguese and the observed genotypic profiles were found related to the ones reported in European populations. The KIR repertoire after hematopoietic stem cell transplantation is determined by these gene frequencies and the KIR group B motifs are the less common. We estimated donor-KIR/recipient-ligand interactions in transplants with related donors and unrelated donors found in a local registry or from abroad. A large fraction of transplants had all three ligands of inhibitory receptors, and therefore, in theory were not prone to natural killer cell (NK) mediated alloreactivity. Furthermore, the distribution of KIR alloreactive interactions was found independent of the donor-recipient genetic proximity, probably because of different gene segregation and comparable KIR frequencies in the donor pools.

KEYWORDS:

hematopoietic stem cell transplantation; killer immunoglobulin-like receptors genotypic diversity; killer immunoglobulin-like receptors-human leukocyte antigen ligand interaction; natural killer cell alloreactivity

PMID:
27075774
DOI:
10.1111/tan.12795
[Indexed for MEDLINE]

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