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PLoS One. 2016 Apr 13;11(4):e0153243. doi: 10.1371/journal.pone.0153243. eCollection 2016.

Implementation of Tuberculosis Intensive Case Finding, Isoniazid Preventive Therapy, and Infection Control ("Three I's") and HIV-Tuberculosis Service Integration in Lower Income Countries.

Collaborators (386)

Ajayi S, Anastos K, Ballif M, Bashi J, Bishai W, Boulle A, Braitstein P, Carriquiry G, Carter JE, Cegielski P, Chimbetete C, Cortes CP, Davies MA, Diero L, Duda S, Durier N, Dusingize JC, Egger M, Eboua TF, Fenner L, Gasser A, Geng E, Gnokori JC, Hardwicke L, Hoffmann C, Huebner R, Kancheya N, Kiertiburanakul S, Kim P, Lameck D, Leroy V, Lewden C, Lindegren ML, Mandalakas A, Maskew M, McKaig R, Mofenson L, Mpoudi-Etame M, Okwara B, Phiri S, Prasitsuebsai W, Petit A, Prozesky H, Reid SE, Renner L, Reubenson G, Sohn A, Sterling T, Vo Q, Walker D, Wehbe F, Wejse C, Wester C, Williams C, Wood R, Wools-Kaloustian K, Yao Z, Yunihastuti E, Zhang FJ, Zhao HX, Han N, Merati TP, Wirawan DN, Yuliana F, Ditangco R, Uy E, Bantique R, Phanuphak P, Ruxrungtham K, Avihingsanon A, Khongphattanayothin M, Kiertiburanakul S, Sungkanuparph S, Sanmeema N, Chaiwarith R, Sirisanthana T, Kotarathititum W, Pham TT, Cuong DD, Ha HL, Nguyen VK, Bui VH, Nguyen TD, Sohn AH, Durier N, Petersen B, Cooper DA, Law MG, Jiamsakul A, Boettiger DC, Wati DK, Atmikasari LP, Malino IY, Nallusamy R, Chan KC, Lumbiganon P, Kosalaraksa P, Tharnprisan P, Udomphanit T, Chokephaibulkit K, Lapphra K, Phongsamart W, Wittawatmongkol O, Dung KT, Lam NV, An PN, Loan NT, Truong HK, Du TQ, Chau NH, Do CV, Ha MT, Sohn AH, Durier N, Nipathakosol P, Cooper DA, Law MG, Kariminia A, Dusingize JC, Mutimura E, Gitembagara A, Anastos K, Tatwangire J, Izabelle I, Niyongabo T, Twizere C, Baramperanye E, Edmonds A, Yotebieng M, Azinyue I, Ayangma L, Ayaya, Bukusi, Cohen, Kulzer, Somi G, Lyamuya R, Ngonyani K, Ssali J, Ssemuwemba H, Mwebesa BB, Kambugu A, Hermans S, Nalugoda F, Jjingo K, Chimbetete C, Dickinson D, Eley B, Fritz C, Garone D, Giddy J, Hoffmann C, MacPhail P, Moultrie H, Ndirangu J, Pestilli S, Phiri S, Prozesky H, Rabie H, Stringer J, Technau K, Wood R, Egger M, Graber C, Kaeser F, Keiser O, Boulle A, Cornell M, Davies MA, Maxwell N, Zannou DM, Ahouada C, Akakpo J, Ahomadegbé C, Bashi J, Gougounon-Houéto A, Azon-Kouanou A, Houngbé F, Sehonou J, Koumakpaï S, Alihonou F, d'Almeida M, Hodonou I, Hounhoui G, Sagbo G, Tossa-Bagnan L, Adjide H, Drabo J, Bognounou R, Dienderé A, Traore E, Zoungrana L, Zerbo B, Sawadogo AB, Zoungrana J, Héma A, Soré I, Bado G, Tapsoba A, Yé D, Kouéta F, Ouedraogo S, Ouédraogo R, Hiembo W, Gansonré M, Messou E, Gnokoro JC, Koné M, Kouakou GM, Bosse CA, Brou K, Assi AI, Chenal H, Hawerlander D, Soppi F, Minga A, Abo Y, Yoboue JM, Eholié SP, Amego MD, Andavi V, Diallo Z, Ello F, Tanon AK, Koule SO, Anzan KC, Guehi C, Aka EA, Issouf KL, Kouakou JC, N'Gbeche MS, Pety T, Avit-Edi D, Kouakou K, Moh M, Yao VA, Folquet MA, Dainguy ME, Kouakou C, Méa-Assande VT, Oka-Berete G, Zobo N, Acquah P, Kokora MB, Eboua TF, Timité-Konan M, Ahoussou LD, Assouan JK, Sami MF, Kouadio C, Renner L, Goka B, Welbeck J, Sackey A, Owiafe SN, Wejse C, Da Silva ZJ, Paulo J, Rodrigues A, da Silva D, Medina C, Oliviera-Souto I, Østergaard L, Laursen A, Sodemann M, Aaby P, Fomsgaard A, Erikstrup C, Eugen-Olsen J, Maïga MY, Diakité FF, Kalle A, Katile D, Traore HA, Minta D, Cissé T, Dembelé M, Doumbia M, Fomba M, Kaya AS, Traoré AM, Traoré H, Toure AA, Dicko F, Sylla M, Berthé A, Traoré HC, Koïta A, Koné N, N'Diaye C, Coulibaly ST, Traoré M, Traoré N, Charurat M, Ajayi S, Alim G, Dapiap S, Otu, Igbinoba F, Benson O, Adebamowo C, James J, Obaseki, Osakede P, Olasode J, Seydi M, Sow PS, Diop B, Manga NM, Tine JM, Bassabi CC, Sy HS, Ba A, Diagne A, Dior H, Faye M, Gueye RD, Mbaye AD, Patassi A, Kotosso A, Kariyare BG, Gbadamassi G, Komi A, Mensah-Zukong KE, Pakpame P, Lawson-Evi AK, Atakouma Y, Takassi E, Djeha A, Ephoévi-gah A, Djibril Sel-H, Dabis F, Bissagnene E, Arrivé E, Coffie P, Ekouevi D, Jaquet A, Leroy V, Lewden C, Sasco AJ, Amani D, Azani JC, Balestre E, Bessekon S, Bohossou F, Gilbert C, Karcher S, Gonsan JM, Le Carrou J, Lenaud S, Nchot C, Malateste K, Yao AR, Siloué B, Clouet G, Dosso M, Doring A, Kouakou A, Rabourdin E, Rivenc J, Anglaret X, Ba B, Essanin JB, Ciaranello A, Datté S, Desmonde S, Diby JS, Gottlieb GS, Horo AG, Kangah SN, Malvy D, Meless D, Mounkaila-Harouna A, Ndondoki C, Shiboski C, Tchounga B, Thiébaut R, Wandeler G, McGowan C, Cahn P, Gotuzzo E, Reyes MW, Grinsztejn B, Pape JW, Padgett D, Madero JS.

Author information

1
Vanderbilt Univ. School of Medicine, Vanderbilt Institute for Global Health (VIGH), Nashville, Tennessee, United States of America.
2
National Hospital of Tropical Diseases, Hanoi, Vietnam.
3
Women's Equity in Access to Care & Treatment, Kigali, Rwanda.
4
MTCTPlus, Abidjan, Cote d'Ivoire.
5
TREAT Asia, amfAR-The Foundation for AIDS Research, Bangkok, Thailand.
6
Infectious Disease Institute, Kampala, Uganda.
7
Rakai Health Sciences Program, Kalisizo, Uganda.
8
University of Chile School of Medicine, Santiago, Chile.
9
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
10
Swiss Tropical and Public Health Institute, Basel, Switzerland.
11
University of Basel, Basel, Switzerland.

Abstract

SETTING:

World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ("Three I's") for TB prevention and control among persons living with HIV.

OBJECTIVE:

To assess the implementation of the "Three I's" of TB-control at HIV treatment sites in lower income countries.

DESIGN:

Survey conducted between March-July, 2012 at 47 sites in 26 countries: 6 (13%) Asia Pacific, 7 (15%), Caribbean, Central and South America, 5 (10%) Central Africa, 8 (17%) East Africa, 14 (30%) Southern Africa, and 7 (15%) West Africa.

RESULTS:

ICF using symptom-based screening was performed at 38% of sites; 45% of sites used symptom-screening plus additional diagnostics. IPT at enrollment or ART initiation was implemented in only 17% of sites, with 9% of sites providing IPT to tuberculin-skin-test positive patients. Infection control measures varied: 62% of sites separated smear-positive patients, and healthcare workers used masks at 57% of sites. Only 12 (26%) sites integrated HIV-TB services. Integration was not associated with implementation of TB prevention measures except for IPT provision at enrollment (42% integrated vs. 9% non-integrated; p = 0.03).

CONCLUSIONS:

Implementation of TB screening, IPT provision, and infection control measures was low and variable across regional HIV treatment sites, regardless of integration status.

PMID:
27073928
PMCID:
PMC4830552
DOI:
10.1371/journal.pone.0153243
[Indexed for MEDLINE]
Free PMC Article

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