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Pathog Dis. 2016 Jun;74(4):ftw031. doi: 10.1093/femspd/ftw031. Epub 2016 Apr 11.

Identification of unique in-frame deletions in OprD among clinical isolates of Pseudomonas aeruginosa.

Author information

1
Infection Innovative Medicines Unit, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA kosscientific@gmail.com.
2
Infection Innovative Medicines Unit, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA.
3
Early Clinical Development Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA 02451, USA.

Abstract

A large percentage of Pseudomonas aeruginosa clinical isolates have been noted to be resistant to carbapenems due to loss of function of the OprD porin, the primary mechanism of entry for carbapenems. Such modifications also substantially abolish the organism's ability to transport arginine. Here we report the identification of an in-frame deletion in oprD which confers carbapenem resistance but is expressed and retains the ability to transport arginine.

KEYWORDS:

OprD; Pseudomonas aerguinosa; carbapenem resistance; porin

PMID:
27073254
DOI:
10.1093/femspd/ftw031
[Indexed for MEDLINE]

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