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Elife. 2016 Apr 13;5:e15938. doi: 10.7554/eLife.15938.

Partners in the Warburg effect.

Author information

1
Department of Chemistry and the Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, United States.
2
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
3
Department of Biological Chemistry, David Geffen School of Medicine, Los Angeles, United States.

Abstract

Cells that surround tumors produce vesicles that supply nutrients to cancer cells and, more surprisingly, also impair the generation of energy in these cancer cells.

KEYWORDS:

cancer metabolism; cell biology; exosomes; human; human biology; macropinocytosis; medicine; metabolic flux analysis; reductive carboxylation; tumor microenvironment

PMID:
27073176
PMCID:
PMC4841767
DOI:
10.7554/eLife.15938
[Indexed for MEDLINE]
Free PMC Article

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