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Oncotarget. 2016 May 17;7(20):29143-53. doi: 10.18632/oncotarget.8661.

Protective effects of alpha lipoic acid on radiation-induced salivary gland injury in rats.

Kim JH1,2, Kim KM3, Jung MH1, Jung JH2,4, Kang KM2,5, Jeong BK2,5, Kim JP2,3, Park JJ2,3, Woo SH2,3.

Author information

1
Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, Gyeongnam, Republic of Korea.
2
Institute of Health Science, Jinju, Gyeongnam, Republic of Korea.
3
Department of Otolaryngology, Jinju, Gyeongnam, Republic of Korea.
4
Department of Internal Medicine, Jinju, Gyeongnam, Republic of Korea.
5
Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Gyeongnam, Republic of Korea.

Abstract

PURPOSE:

Radiation therapy is a treatment for patients with head and neck (HN) cancer. However, radiation exposure to the HN often induces salivary gland (SG) dysfunction. We investigated the effect of α-lipoic acid (ALA) on radiation-induced SG injury in rats.

RESULTS:

ALA preserved acinoductal integrity and acinar cell secretary function following irradiation. These results are related to the mechanisms by which ALA inhibits oxidative stress by inhibiting gp91 mRNA and 8-OHdG expression and apoptosis of acinar cells and ductal cells by inactivating MAPKs in the early period and expression of inflammation-related factors including NF-κB, IκB-α, and TGF-β1 and fibrosis in late irradiated SG. ALA effects began in the acute phase and persisted for at least 56 days after irradiation.

MATERIALS AND METHODS:

Rats were assigned to followings: control, ALA only (100 mg/kg, i.p.), irradiated, and ALA administered 24 h and 30 min prior to irradiation. The neck area including the SG was evenly irradiated with 2 Gy per minute (total dose, 18 Gy) using a photon 6-MV linear accelerator. Rats were killed at 4, 7, 28, and 56 days after radiation.

CONCLUSIONS:

Our results show that ALA could be used to ameliorate radiation-induced SG injury in patients with HN cancer.

KEYWORDS:

Nox-2; alpha lipoic acid; complication; radiation; salivary gland

PMID:
27072584
PMCID:
PMC5045384
DOI:
10.18632/oncotarget.8661
[Indexed for MEDLINE]
Free PMC Article

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