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Future Microbiol. 2016;11(4):567-83. doi: 10.2217/fmb.16.1. Epub 2016 Apr 12.

Adaptation of Candida albicans to commensalism in the gut.

Author information

1
Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Abstract

Candida albicans is a common resident of the oral cavity, GI tract and vagina in healthy humans where it establishes a commensal relationship with the host. Colonization of the gut, which is an important niche for the microbe, may lead to systemic dissemination and disease upon alteration of host defences. Understanding the mechanisms responsible for the adaptation of C. albicans to the gut is therefore important for the design of new ways of combating fungal diseases. In this review we discuss the available models to study commensalism of this yeast, the main mechanisms controlling the establishment of the fungus, such as microbiota, mucus layer and antimicrobial peptides, and the gene regulatory circuits that ensure its survival in this niche.

KEYWORDS:

Candida albicans; adaptation; commensalism; fitness; mouse gut

PMID:
27070839
DOI:
10.2217/fmb.16.1
[Indexed for MEDLINE]

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