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Ocul Immunol Inflamm. 2017 Oct;25(5):589-595. doi: 10.3109/09273948.2016.1158278. Epub 2016 Apr 12.

Birdshot Retinochoroidopathy: Differences in Clinical Characteristics between Patients with Early and Late Age of Onset.

Author information

1
a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA.
2
b Ocular Immunology & Uveitis Foundation , Waltham , Massachusetts , USA.
3
c Department of Ophthalmology, Faculty of Medicine, Rajavithi Hospital, College of Medicine , Rangsit University , Bangkok , Thailand.
4
d Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital , Mahidol University , Bangkok , Thailand.
5
e Harvard Medical School , Boston , Massachusetts , USA.

Abstract

PURPOSE:

To describe differences in the clinical characteristics of birdshot retinochoroidopathy (BSRC) patients diagnosed early and later in life.

METHODS:

This is a retrospective cohort study. Age was primarily analyzed and 50 years of age at diagnosis was selected as a cut-off point.

RESULTS:

A total of 144 patients (288 eyes) were included; 68 with early-onset and 76 with late-onset BSRC. The younger group had a statistically significant higher rate of more severe iritis (p = 0.04); an average number of non-steroidal immunosuppressants and biologic agents (NSIB) (p = 0.04); and a prolonged time to initiation of NSIB (p = 0.01). There were only four patients (3%) who had >0.5+ cells in the anterior chamber.

CONCLUSIONS:

Patients with early-onset BSRC carried a higher risk for anterior segment inflammation, had a more prolonged delay to initiation of treatment with NSIB, and required a greater number of NSIBs to achieve remission.

KEYWORDS:

Birdshot retinochoroidopathy; early-onset; inflammation; late-onset

PMID:
27070723
DOI:
10.3109/09273948.2016.1158278
[Indexed for MEDLINE]

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