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Cancer Cell. 2016 Apr 11;29(4):610-610.e1. doi: 10.1016/j.ccell.2016.03.021.

SnapShot: Renal Cell Carcinoma.

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1
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

Abstract

Renal cell carcinoma (RCC) is a heterogeneous disease made up of a number of different cancer types, with distinct histologies, clinical courses, therapeutic responses, and genetic drivers. Germline mutations in 14 genes have been associated with increased risk of RCC and can result in HIF pathway activation, chromatin dysregulation, and altered metabolism. Knowledge of these pathway alterations can inform the development of targeted therapeutic approaches. To view this SnapShot, open or download the PDF.

PMID:
27070709
DOI:
10.1016/j.ccell.2016.03.021
[Indexed for MEDLINE]
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