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Nano Lett. 2016 May 11;16(5):3042-50. doi: 10.1021/acs.nanolett.6b00054. Epub 2016 Apr 12.

Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility.

Author information

1
Department of Materials Science and Engineering Northwestern University , Evanston, Illinois 60208, United States.
2
Simpson Querrey Institute for BioNanotechnology, Northwestern University , Chicago, Illinois 60611, United States.
3
Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, The University of Southern California , Los Angeles, California 90033, United States.
4
Department of Biomedical Engineering, Northwestern University , Evanston, Illinois 60208, United States.
5
Department of Chemistry, Northwestern University , Evanston, Illinois 60208, United States.
6
Department of Medicine, Northwestern University , Chicago, Illinois 60611, United States.

Abstract

The nanostructures of self-assembling biomaterials have been previously designed to tune the release of growth factors in order to optimize biological repair and regeneration. We report here on the discovery that weakly cohesive peptide nanostructures in terms of intermolecular hydrogen bonding, when combined with low concentrations of osteogenic growth factor, enhance both BMP-2 and Wnt mediated signaling in myoblasts and bone marrow stromal cells, respectively. Conversely, analogous nanostructures with enhanced levels of internal hydrogen bonding and cohesion lead to an overall reduction in BMP-2 signaling. We propose that the mechanism for enhanced growth factor signaling by the nanostructures is related to their ability to increase diffusion within membrane lipid rafts. The phenomenon reported here could lead to new nanomedicine strategies to mediate growth factor signaling for translational targets.

KEYWORDS:

BMP-2; LRAP; Self-assembly; growth factor signaling; lipid raft

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