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Brief Funct Genomics. 2017 May 1;16(3):121-128. doi: 10.1093/bfgp/elw012.

Systematic review of next-generation sequencing simulators: computational tools, features and perspectives.

Abstract

High-throughput next-generation sequencing (NGS) technologies have rapidly generated a large volume of genomic data. To aid the development and evaluation of new statistical models and computational methods, NGS-based simulators have been proposed to construct better experimental workflows. However, the comparative performance of these NGS simulators remains unclear. In this review, we conducted a comprehensive investigation of NGS simulators for various sequencing techniques, including DNA sequencing, metagenomic sequencing, RNA-seq, ChIP-seq and bisulfite sequencing for methylation.

KEYWORDS:

high-throughput next-generation sequencing; simulator

PMID:
27069250
DOI:
10.1093/bfgp/elw012
[Indexed for MEDLINE]

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