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Anticancer Res. 2016 Apr;36(4):2019-26.

Prognosis of Castration-resistant Prostate Cancer Patients - Use of the AdnaTest® System for Detection of Circulating Tumor Cells.

Author information

1
Department of Urology, General University Hospital and of The First Faculty of Medicine of Charles University otakar.capoun@seznam.cz.
2
Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and of The First Faculty of Medicine of Charles University.
3
Department of Oncology, General University Hospital and of The First Faculty of Medicine of Charles University.
4
Department of Tumor Biology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
5
Department of Urology, General University Hospital and of The First Faculty of Medicine of Charles University.

Abstract

BACKGROUND:

Detection of circulating tumor cells (CTC) in patients with castration-resistant prostate cancer (CRPC) may improve the estimate of chemotherapy response. We evaluated the AdnaTest® system in patients receiving docetaxel.

PATIENTS AND METHODS:

CTC analysis was carried out in 37 patients by immunomagnetic separation. Correlation between serum prostate-specific antigen (sPSA) change and CTC presence and the influence of each parameter on the overall survival (OS) were evaluated.

RESULTS:

We detected CTCs in 32 and 16 patients before and after three docetaxel cycles, respectively. The sPSA level correlated with CTC positivity during docetaxel therapy (p=0.0031). The longest OS was in patients negative for CTCs in both samples (p=0.0228). Change in sPSA levels was associated with treatment response (p=0.033).

CONCLUSION:

We detected CTCs in a considerable number of patients with CRPC. The absolute change of sPSA level correlated with OS. CTC presence during docetaxel therapy was associated with shorter OS.

KEYWORDS:

AdnaTest; castration-resistant prostate cancer; chemotherapy; circulating tumor cells; prognosis

PMID:
27069196
[Indexed for MEDLINE]

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