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Dent Mater. 2016 Jun;32(6):784-93. doi: 10.1016/j.dental.2016.03.026. Epub 2016 Apr 8.

Novel hydroxyapatite nanorods improve anti-caries efficacy of enamel infiltrants.

Author information

1
Group of Chemistry of Advanced Materials (GQMAT) - Department of Analytical Chemistry and Physic-chemistry, Federal University of Ceará - UFC, Campus do Pici, CP 12100, Zip Code 60451-970, Fortaleza, Brazil.
2
Post-Graduate Program in Dentistry - Department of Restorative Dentistry, Federal University of Ceará, Fortaleza, Brazil.
3
Post-Graduate Program in Dentistry - Department of Restorative Dentistry, Federal University of Ceará, Fortaleza, Brazil. Electronic address: victorpfeitosa@hotmail.com.
4
Post-Graduate Program in Dentistry - Department of Restorative Dentistry, Federal University of Ceará, Fortaleza, Brazil; Dental Biomaterials - Departmento de Odontologia, Facultad de Ciencias de la Salud, CEU-Cardenal Herrera University, Alfara del Patriarca, 46115 Valencia, Spain.
5
Dipartimento di Ingegneria dell'Innovazione, Università del Salento, Via Arnesano, 73100 Lecce, Italy.
6
CNR-IPCF UOS Pisa, Via G. Moruzzi 1 - 56124 Pisa, Italy.
7
Group of Chemistry of Advanced Materials (GQMAT) - Department of Analytical Chemistry and Physic-chemistry, Federal University of Ceará - UFC, Campus do Pici, CP 12100, Zip Code 60451-970, Fortaleza, Brazil. Electronic address: fechine@ufc.br.

Abstract

OBJECTIVES:

Enamel resin infiltrants are biomaterials able to treat enamel caries at early stages. Nevertheless, they cannot prevent further demineralization of mineral-depleted enamel. Therefore, the aim of this work was to synthesize and incorporate specific hydroxyapatite nanoparticles (HAps) into the resin infiltrant to overcome this issue.

METHODS:

HAps were prepared using a hydrothermal method (0h, 2h and 5h). The crystallinity, crystallite size and morphology of the nanoparticles were characterized through XRD, FT-IR and TEM. HAps were then incorporated (10wt%) into a light-curing co-monomer resin blend (control) to create different resin-based enamel infiltrants (HAp-0h, HAp-2h and HAp-5h), whose degree of conversion (DC) was assessed by FT-IR. Enamel caries lesions were first artificially created in extracted human molars and infiltrated using the tested resin infiltrants. Specimens were submitted to pH-cycling to simulate recurrent caries. Knoop microhardness of resin-infiltrated underlying and surrounding enamel was analyzed before and after pH challenge.

RESULTS:

Whilst HAp-0h resulted amorphous, HAp-2h and HAp-5h presented nanorod morphology and higher crystallinity. Resin infiltration doped with HAp-2h and HAp-5h caused higher enamel resistance against demineralization compared to control HAp-free and HAp-0h infiltration. The inclusion of more crystalline HAp nanorods (HAp-2h and HAp-5h) increased significantly (p<0.05) the DC.

SIGNIFICANCE:

Incorporation of more crystalline HAp nanorods into enamel resin infiltrants may be a feasible method to improve the overall performance in the prevention of recurrent demineralization (e.g. caries lesion) in resin-infiltrated enamel.

KEYWORDS:

Caries; Composite materials; Dimethacrylate; Nanotechnology

PMID:
27068739
DOI:
10.1016/j.dental.2016.03.026
[Indexed for MEDLINE]

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