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Lipids. 2016 Jun;51(6):693-702. doi: 10.1007/s11745-016-4147-8. Epub 2016 Apr 11.

Cinnamomum camphora Seed Kernel Oil Improves Lipid Metabolism and Enhances β3-Adrenergic Receptor Expression in Diet-Induced Obese Rats.

Fu J1, Zeng C2, Zeng Z3,4,5, Wang B1, Wen X6, Yu P6, Gong D1,7,8.

Author information

1
State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China.
2
The First Clinical School, Nanchang University, Nanchang, 330031, China.
3
State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China. zlzengjx@163.com.
4
School of Environmental and Chemical Engineering, Nanchang University, Nanchang, 330031, China. zlzengjx@163.com.
5
Jiangxi Province Key Laboratory of Edible and Medicinal Plant Resources, Nanchang University, Nanchang, 330031, China. zlzengjx@163.com.
6
School of Environmental and Chemical Engineering, Nanchang University, Nanchang, 330031, China.
7
Jiangxi Province Key Laboratory of Edible and Medicinal Plant Resources, Nanchang University, Nanchang, 330031, China.
8
School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

Abstract

The effects of dietary Cinnamomum camphora seed kernel oil (CCSKO) containing medium-chain triacylglycerols on lipid metabolism and mRNA and protein expression of β-3 adrenergic receptor in adipose tissue were studied in diet-induced obese rats. High fat food-induced obese rats were randomly divided into CCSKO group, Lard group, Soybean oil (SOY) group and naturally restoring group (n = 10). Rats fed with low fat food were used as a normal control group. Significant decreases in body mass and abdominal fat mass/body mass after 12 weeks were found in CCSKO group as compared with Lard and SOY groups (p < 0.05). Levels of blood total cholesterol (TC), triglyceride, free fatty acid, fasting insulin and insulin resistance in the CCSKO group were decreased significantly, and noradrenaline level and insulin sensitivity index in the CCSKO group were significantly higher than other groups. Meanwhile liver TC and triglyceride levels in the CCSKO group were also decreased markedly. Expression levels of β3-adrenergic receptor mRNA and protein were higher in CCSKO group than in Lard and SOY groups. These results suggest that CCSKO may contribute to reduction of the body fat mass, promote lipid metabolism and up-regulate β3-adrenergic receptor expression in high fat diet-induced obese rats.

KEYWORDS:

Body fat; Cinnamomum camphora seeds kernel oil; Lipid metabolism; Medium-chain triacylglycerols; β-3 Adrenergic receptor

PMID:
27068065
DOI:
10.1007/s11745-016-4147-8
[Indexed for MEDLINE]

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