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Antimicrob Agents Chemother. 2016 Jun 20;60(7):4339-41. doi: 10.1128/AAC.00504-16. Print 2016 Jul.

New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan.

Author information

1
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
2
Sonezaki Furubayashi Clinic, Osaka, Japan.
3
Osaka Prefectural Institute of Public Health, Osaka, Japan.
4
WHO Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.
5
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan ohnishi7@niid.go.jp.

Abstract

We have characterized in detail a new ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain (FC428) isolated in Japan in 2015. FC428 differed from previous ceftriaxone-resistant strains and contained a novel mosaic penA allele encoding a new mosaic penicillin-binding protein 2 (PBP 2). However, the resistance-determining 3'-terminal region of penA was almost identical to the regions of two previously reported ceftriaxone-resistant strains from Australia and Japan, indicating that both ceftriaxone-resistant strains and conserved ceftriaxone resistance-determining PBP 2 regions might spread.

PMID:
27067334
PMCID:
PMC4914677
DOI:
10.1128/AAC.00504-16
[Indexed for MEDLINE]
Free PMC Article

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