Format

Send to

Choose Destination
Commun Integr Biol. 2015 Aug 27;8(5):e1073424. doi: 10.1080/19420889.2015.1073424. eCollection 2015 Sep-Oct.

The stability of memories during brain remodeling: A perspective.

Author information

1
Center for Regenerative and Developmental Biology and Department of Biology; Tufts University ; Medford, MA USA.
2
Department of Neurobiology; Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus; Jerusalem, Israel; School of Marine Sciences, Ruppin Academic Center; Michmoret, Israel.

Abstract

One of the most important features of the nervous system is memory: the ability to represent and store experiences, in a manner that alters behavior and cognition at future times when the original stimulus is no longer present. However, the brain is not always an anatomically stable structure: many animal species regenerate all or part of the brain after severe injury, or remodel their CNS toward a new configuration as part of their life cycle. This raises a fascinating question: what are the dynamics of memories during brain regeneration? Can stable memories remain intact when cellular turnover and spatial rearrangement modify the biological hardware within which experiences are stored? What can we learn from model species that exhibit both, regeneration and memory, with respect to robustness and stability requirements for long-term memories encoded in living tissues? In this Perspective, we discuss relevant data in regenerating planaria, metamorphosing insects, and hibernating ground squirrels. While much remains to be done to understand this remarkable process, molecular-level insight will have important implications for cognitive science, regenerative medicine of the brain, and the development of non-traditional computational media in synthetic bioengineering.

KEYWORDS:

brain; learning; memory; metamorphosis; regeneration; remodeling

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center