A Robust Feedforward Model of the Olfactory System

PLoS Comput Biol. 2016 Apr 11;12(4):e1004850. doi: 10.1371/journal.pcbi.1004850. eCollection 2016 Apr.

Abstract

Most natural odors have sparse molecular composition. This makes the principles of compressed sensing potentially relevant to the structure of the olfactory code. Yet, the largely feedforward organization of the olfactory system precludes reconstruction using standard compressed sensing algorithms. To resolve this problem, recent theoretical work has shown that signal reconstruction could take place as a result of a low dimensional dynamical system converging to one of its attractor states. However, the dynamical aspects of optimization slowed down odor recognition and were also found to be susceptible to noise. Here we describe a feedforward model of the olfactory system that achieves both strong compression and fast reconstruction that is also robust to noise. A key feature of the proposed model is a specific relationship between how odors are represented at the glomeruli stage, which corresponds to a compression, and the connections from glomeruli to third-order neurons (neurons in the olfactory cortex of vertebrates or Kenyon cells in the mushroom body of insects), which in the model corresponds to reconstruction. We show that should this specific relationship hold true, the reconstruction will be both fast and robust to noise, and in particular to the false activation of glomeruli. The predicted connectivity rate from glomeruli to third-order neurons can be tested experimentally.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Animals
  • Computational Biology
  • Feedback, Physiological
  • Humans
  • Models, Neurological*
  • Odorants
  • Olfactory Bulb / physiology
  • Olfactory Pathways / physiology*
  • Olfactory Receptor Neurons / physiology
  • Receptors, Odorant / physiology
  • Smell / physiology*

Substances

  • Receptors, Odorant