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Osteoarthritis Cartilage. 2016 Aug;24(8):1330-9. doi: 10.1016/j.joca.2016.03.018. Epub 2016 Apr 5.

Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus.

Author information

1
Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Saar, Germany. Electronic address: mmcucchiarini@hotmail.com.
2
Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, USA.
3
McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
4
Center of Regenerative Medicine, Departments of Orthopaedic Surgery, Developmental Biology, and Biomedical Engineering, Shriners Hospitals for Children, Washington University, St. Louis, MO, USA; Shriners Hospitals for Children, St. Louis, MO, USA.
5
Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Saar, Germany; Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Saar, Germany.

Abstract

Meniscal lesions are common problems in orthopaedic surgery and sports medicine, and injury or loss of the meniscus accelerates the onset of knee osteoarthritis (OA). Despite a variety of therapeutic options in the clinics, there is a critical need for improved treatments to enhance meniscal repair. In this regard, combining gene-, cell-, and tissue engineering-based approaches is an attractive strategy to generate novel, effective therapies to treat meniscal lesions. In the present work, we provide an overview of the tools currently available to improve meniscal repair and discuss the progress and remaining challenges for potential future translation in patients.

KEYWORDS:

Cell therapy; Gene therapy; Meniscal repair; Meniscus; Tissue engineering

PMID:
27063441
PMCID:
PMC5298218
DOI:
10.1016/j.joca.2016.03.018
[Indexed for MEDLINE]
Free PMC Article

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