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Clin Liver Dis. 2016 May;20(2):325-38. doi: 10.1016/j.cld.2015.10.003. Epub 2015 Dec 14.

The Progression and Natural History of Pediatric Nonalcoholic Fatty Liver Disease.

Author information

1
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, San Diego, CA, USA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA, USA.
2
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, San Diego, CA, USA; Department of Gastroenterology, Rady Children's Hospital, San Diego, CA, USA. Electronic address: jschwimmer@ucsd.edu.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States. Childhood NAFLD is associated with hepatic and nonhepatic morbidity and mortality. Nonhepatic associations include cardiovascular, metabolic, pulmonary, and psychological disorders. Cardiovascular conditions observed in childhood include left ventricular dysfunction. Furthermore, childhood obesity is associated with greater odds of having hepatocellular carcinoma as an adult. Evidence suggests that NAFLD may begin in utero in children of diabetic mothers. Thus rigorous efforts for structured diagnosis and follow-up are a priority to better develop the understanding of outcomes in pediatric NAFLD.

KEYWORDS:

Adolescents; Children; Epidemiology; Morbidity; Mortality; Nonalcoholic steatohepatitis; Obesity; Outcomes

PMID:
27063272
PMCID:
PMC4829737
DOI:
10.1016/j.cld.2015.10.003
[Indexed for MEDLINE]
Free PMC Article

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