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Semin Cell Dev Biol. 2016 Aug;56:35-47. doi: 10.1016/j.semcdb.2016.04.002. Epub 2016 Apr 6.

The "lnc" between 3D chromatin structure and X chromosome inactivation.

Author information

1
Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA.
2
Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: KPlath@mednet.ucla.edu.

Abstract

The long non-coding RNA Xist directs a remarkable instance of developmentally regulated, epigenetic change known as X Chromosome Inactivation (XCI). By spreading in cis across the X chromosome from which it is expressed, Xist RNA facilitates the creation of a heritably silent, heterochromatic nuclear territory that displays a three-dimensional structure distinct from that of the active X chromosome. How Xist RNA attaches to and propagates across a chromosome and its influence over the three-dimensional (3D) structure of the inactive X are aspects of XCI that have remained largely unclear. Here, we discuss studies that have made significant contributions towards answering these open questions.

KEYWORDS:

Chromosome conformation; Heterochromatin; Non-coding RNA; X chromosome inactivation Xist

PMID:
27062886
PMCID:
PMC4955722
DOI:
10.1016/j.semcdb.2016.04.002
[Indexed for MEDLINE]
Free PMC Article

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