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Curr Opin Cell Biol. 2016 Aug;41:25-32. doi: 10.1016/j.ceb.2016.03.012. Epub 2016 Apr 7.

Lipid unsaturation and organelle dynamics.

Author information

1
Institut de Pharmacologie Moléculaire et Cellulaire, 660 route des lucioles, 06560 Valbonne, France. Electronic address: barelli@ipmc.cnrs.fr.
2
Institut de Pharmacologie Moléculaire et Cellulaire, 660 route des lucioles, 06560 Valbonne, France. Electronic address: antonny@ipmc.cnrs.fr.

Abstract

The number of double bonds (=unsaturation) in the acyl chains of phospholipids (PL) influences the physical properties of cellular membranes. Here, we discuss disparate molecular processes, including vesicle budding, ion channel opening, and lipoprotein formation, which are greatly facilitated by PL polyunsaturation in membranes. Experimental and computer-based approaches for the structure and dynamics of PL suggest a common cause for these effects: the ability of the polyunsaturated acyl chain of PL to extend or bent along the membrane normal according to various constraints, thereby enabling a third dimension of motion in a structure that is essentially a 2D fluid.

PMID:
27062546
DOI:
10.1016/j.ceb.2016.03.012
[Indexed for MEDLINE]

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