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J Back Musculoskelet Rehabil. 2016 Nov 21;29(4):835-839.

Does vitamin D deficiency trigger carpal tunnel syndrome?

Author information

1
Department of Neurology, Bozok University Medical School, Yozgat, Turkey.
2
Department of Physical Treatment and Rehabilitation, Bozok University Medical School, Yozgat, Turkey.
3
Department of Physical Medicine and Rehabilitation, Yozgat State Hospital, Yozgat, Turkey.
4
Department of Neurosurgery, Bozok University Medical School, Yozgat, Turkey.
5
Department of Biochemistry, Bozok University Medical School, Yozgat, Turkey.

Abstract

OBJECTIVE:

Vitamin D deficiencies are associated with a variety of chronic diseases. The goal of the present study was to investigate the relationship between vitamin D levels and carpal tunnel syndrome (CTS).

METHODS:

This study included 90 patients with mild to moderate CTS and assessed their routine serum 25-hydroxyvitamin D levels. Additionally, the pain level of each subject was evaluated using the Visual Analogue Scale and the Douleur Neuropathique 4 Questionnaire (DN4).

RESULTS:

The severity levels of CTS were at a 75% mild level in the vitamin D deficiency group and a 47.1% mild level in the vitamin D normal group, with a significant difference between groups (p = 0.008). Correlation analyses revealed positive correlations between body mass index and DN4 scores (r = 0.499, p = 0.025) and between vitamin D levels and CTS severity (r = 0.364, p = 0.004) in the vitamin D deficiency group.

CONCLUSIONS:

The present findings demonstrated that CTS may be triggered by vitamin D deficiency, and that the severity of CTS was correlated with vitamin D levels in the deficiency group. Additionally, there was a correlation between weight gain and neuropathic pain intensity in CTS patients with vitamin D deficiency. The present findings indicate that vitamin D levels should be assessed in CTS patients.

KEYWORDS:

25-Dihydroxyvitamin; carpal tunnel syndrome; neuropathic pain

PMID:
27062466
DOI:
10.3233/BMR-160696
[Indexed for MEDLINE]

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