Format

Send to

Choose Destination
J Hum Nutr Diet. 2016 Aug;29(4):516-22. doi: 10.1111/jhn.12361. Epub 2016 Apr 8.

Vitamin E supplementation inhibits muscle damage and inflammation after moderate exercise in hypoxia.

Author information

1
Department of Bioscience, Universidade Federal de São Paulo, Santos, Brazil.
2
Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
3
Department of Physical Education, Universidade Estadual Paulista, Presidente Prudente, Brazil.

Abstract

BACKGROUND:

Exercise under hypoxic conditions represents an additional stress in relation to exercise in normoxia. Hypoxia induces oxidative stress and inflammation as mediated through tumour necrosis factor (TNF)-α release that might be exacerbated through exercise. In addition, vitamin E supplementation might attenuate oxidative stress and inflammation resulting from hypoxia during exercise. The present study aimed to evaluate the effects of vitamin E supplementation (250 mg) on inflammatory parameters and cellular damage after exercise under hypoxia simulating an altitude of 4200 m.

METHODS:

Nine volunteers performed three sessions of 60 min of exercise (70% maximal oxygen uptake) interspersed for 1 week under normoxia, hypoxia and hypoxia after vitamin E supplementation 1 h before exercise. Blood was collected before, immediately after and at 1 h after exercise to measure inflammatory parameters and cell damage.

RESULTS:

Percentage oxygen saturation of haemoglobin decreased after exercise and recovered 1 h later in the hypoxia + vitamin condition (P < 0.05). Supplementation decreased creatine kinase (CK)-TOTAL, CK-MB and lactate dehydrogenase 1 h after exercise (P < 0.05). The exercise in hypoxia increased interleukin (IL)-6, TNF-α, IL-1ra and IL-10 immediately after exercise (P < 0.05). Supplementation reversed the changes observed after exercise in hypoxia without supplementation (P < 0.05).

CONCLUSIONS:

We conclude that 250 mg of vitamin E supplementation at 1 h before exercise reduces cell damage markers after exercise in hypoxia and changes the concentration of cytokines, suggesting a possible protective effect against inflammation induced by hypoxia during exercise.

KEYWORDS:

altitude; cellular damage; inflammation; physical exercise; supplementation; vitamin E

PMID:
27062041
DOI:
10.1111/jhn.12361
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center