Format

Send to

Choose Destination
Clin Pharmacol Ther. 2016 May;99(5):512-27. doi: 10.1002/cpt.343. Epub 2016 Feb 19.

DNA Methylation of ADME Genes.

Author information

1
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
2
University of Tübingen, Tübingen, Germany.
3
Department of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany.
4
Department of Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany.

Abstract

The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to interindividual variability in drug response. Epigenetic mechanisms include DNA methylation, histone modifications, and miRNAs. This review systematically outlines the influence of DNA methylation on ADME gene expression and highlights the consequences for interindividual variability in drug response or drug-induced toxicity and the implications for personalized medicine.

PMID:
27061006
DOI:
10.1002/cpt.343
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center