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J Pediatr. 2016 Jun;173:232-4. doi: 10.1016/j.jpeds.2016.03.034. Epub 2016 Apr 5.

Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth.

Author information

1
Division of Pediatric Endocrinology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI. Electronic address: apollock@pediatrics.wisc.edu.
2
Case Western Reserve University School of Medicine, Cleveland, OH.
3
Division of Pediatric Endocrinology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Abstract

Thyroid dysfunction in adolescents treated with minocycline for acne has been previously described as transient effect and/or associated with autoimmune thyroiditis. We report nonimmune-mediated thyroid dysfunction associated with minocycline/doxycycline in 3 adolescents whose clinical courses suggest an adverse effect that may be more common, serious, and persistent than realized previously.

KEYWORDS:

acne vulgaris; doxycycline; hyperthyroidism; hypothyroidism; minocycline; tetracycline; thyroid dysfunction; thyroiditis

PMID:
27059913
PMCID:
PMC4884496
DOI:
10.1016/j.jpeds.2016.03.034
[Indexed for MEDLINE]
Free PMC Article

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