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Cell. 2016 Apr 7;165(2):264-5. doi: 10.1016/j.cell.2016.03.012.

Insulin Signaling in a Bit of a Jam.

Author information

1
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA.
2
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA; Departments of Physiology and Medicine, University of California, San Francisco, San Francisco, CA 94158-9001, USA. Electronic address: ajay.chawla@ucsf.edu.

Abstract

In this issue of Cell, Okin and Medzhitov report that sustained inflammation promotes hyperglycemia by targeting the mevalonate pathway. This represents an important step forward in understanding the mechanisms underlying the association between chronic low-grade inflammation and disruption of normal tissue functions in metabolic diseases.

PMID:
27058657
DOI:
10.1016/j.cell.2016.03.012
[Indexed for MEDLINE]
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