Format

Send to

Choose Destination
Oncotarget. 2016 May 3;7(18):26680-91. doi: 10.18632/oncotarget.8589.

Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer.

Xie H1,2, Ren X1,2, Xin S1,2, Lan X3, Lu G1,2, Lin Y1,2, Yang S1,2, Zeng Z1,2, Liao W1,2, Ding YQ1,2, Liang L1,2.

Author information

1
Department of Pathology, Nanfang Hospital, Guangzhou, Guangdong, China.
2
Guangdong Province Key Laboratory of Molecular Tumor Pathology, Guangzhou, Guangdong, China.
3
Department of General Surgery, Nanfang Hospital, Guangzhou, Guangdong, China.

Abstract

Circular RNAs (circRNAs), a large class of RNAs, have recently shown huge capabilities as gene regulators in mammals. Some of them bind with microRNAs (miRNAs) and act as natural miRNA sponges to inhibit related miRNAs' activities. Here we showed that hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer (CRC). Moreover, hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2. In CRC tissues, circ_001569 negatively correlated with miR-145, and miR-145 correlated negatively with E2F5, BAG4 and FMNL2 expressions. Our study reveals a novel regulatory mechanism of circ_001569 in cell proliferation and invasion in CRC, provides a comprehensive landscape of circ_001569 that will facilitate further biomarker discoveries in the progression of CRC.

KEYWORDS:

BAG4; FMNL2; colorectal cancer; hsa_circ_001569; miR-145

PMID:
27058418
PMCID:
PMC5042007
DOI:
10.18632/oncotarget.8589
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Impact Journals, LLC Icon for PubMed Central
Loading ...
Support Center