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Clin Infect Dis. 2016 Jul 1;63(1):133-137. doi: 10.1093/cid/ciw213. Epub 2016 Apr 7.

Antiretroviral Drug Resistance Among Children and Youth in the United States With Perinatal HIV.

Author information

1
Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana.
2
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
3
Focus Diagnostics, a Quest Diagnostics Subsidiary, San Juan Capistrano, California.
4
Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
5
Quest Diagnostics, Baltimore, Maryland.
6
Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans.
7
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
8
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.

Abstract

Among 234 US youths with perinatal human immunodeficiency virus, 75% had antiretroviral resistance, substantially higher than that of the reference laboratory overall (36%-44%). Resistance to newer antiretrovirals and to all antiretrovirals in a class was uncommon. The only factor independently associated with future resistance was a higher peak viral load.

KEYWORDS:

adolescents; antiviral resistance; children; human immunodeficiency virus; perinatal infection

PMID:
27056398
PMCID:
PMC4901868
DOI:
10.1093/cid/ciw213
[Indexed for MEDLINE]
Free PMC Article

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